MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Glenn D. Graham; P. B. Barker; W. M. Brooks; D. C. Morris; W. Ahmed; E. Bryniarski; D. O. Hearshen; J. A. Sanders; B. A. Holshouser; C. C. Turkel

doi:10.1212/wnl.55.9.1376

MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Glenn D. Graham
, P. B. Barker
, W. M. Brooks
, D. C. Morris
, W. Ahmed
, E. Bryniarski
, D. O. Hearshen
, J. A. Sanders
, B. A. Holshouser
, C. C. Turkel

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In a double-blind, placebo-controlled study, we used ¹H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

Original language	English (US)
Pages (from-to)	1376-1378
Number of pages	3
Journal	Neurology
Volume	55
Issue number	9
DOIs	https://doi.org/10.1212/wnl.55.9.1376
State	Published - Nov 14 2000
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "MR spectroscopy study of dichloroacetate treatment after ischemic stroke",

abstract = "In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.",

author = "Graham, \{Glenn D.\} and Barker, \{P. B.\} and Brooks, \{W. M.\} and Morris, \{D. C.\} and W. Ahmed and E. Bryniarski and Hearshen, \{D. O.\} and Sanders, \{J. A.\} and Holshouser, \{B. A.\} and Turkel, \{C. C.\}",

year = "2000",

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doi = "10.1212/wnl.55.9.1376",

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TY - JOUR

T1 - MR spectroscopy study of dichloroacetate treatment after ischemic stroke

AU - Graham, Glenn D.

AU - Barker, P. B.

AU - Brooks, W. M.

AU - Morris, D. C.

AU - Ahmed, W.

AU - Bryniarski, E.

AU - Hearshen, D. O.

AU - Sanders, J. A.

AU - Holshouser, B. A.

AU - Turkel, C. C.

PY - 2000/11/14

Y1 - 2000/11/14

N2 - In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

AB - In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

UR - https://www.scopus.com/pages/publications/0034649386

UR - https://www.scopus.com/pages/publications/0034649386#tab=citedBy

U2 - 10.1212/wnl.55.9.1376

DO - 10.1212/wnl.55.9.1376

M3 - Article

C2 - 11087784

AN - SCOPUS:0034649386

SN - 0028-3878

VL - 55

SP - 1376

EP - 1378

JO - Neurology

JF - Neurology

IS - 9

ER -

MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Abstract

ASJC Scopus subject areas

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