MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Glenn D. Graham; P. B. Barker; W. M. Brooks; D. C. Morris; W. Ahmed; E. Bryniarski; D. O. Hearshen; J. A. Sanders; B. A. Holshouser; C. C. Turkel

doi:10.1212/wnl.55.9.1376

MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Glenn D. Graham, P. B. Barker, W. M. Brooks, D. C. Morris, W. Ahmed, E. Bryniarski, D. O. Hearshen, J. A. Sanders, B. A. Holshouser, C. C. Turkel

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11 Scopus citations

Abstract

In a double-blind, placebo-controlled study, we used ¹H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

Original language	English (US)
Pages (from-to)	1376-1378
Number of pages	3
Journal	Neurology
Volume	55
Issue number	9
DOIs	https://doi.org/10.1212/wnl.55.9.1376
State	Published - Nov 14 2000
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "MR spectroscopy study of dichloroacetate treatment after ischemic stroke",

abstract = "In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.",

author = "Graham, {Glenn D.} and Barker, {P. B.} and Brooks, {W. M.} and Morris, {D. C.} and W. Ahmed and E. Bryniarski and Hearshen, {D. O.} and Sanders, {J. A.} and Holshouser, {B. A.} and Turkel, {C. C.}",

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T1 - MR spectroscopy study of dichloroacetate treatment after ischemic stroke

AU - Graham, Glenn D.

AU - Barker, P. B.

AU - Brooks, W. M.

AU - Morris, D. C.

AU - Ahmed, W.

AU - Bryniarski, E.

AU - Hearshen, D. O.

AU - Sanders, J. A.

AU - Holshouser, B. A.

AU - Turkel, C. C.

PY - 2000/11/14

Y1 - 2000/11/14

N2 - In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

AB - In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

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VL - 55

SP - 1376

EP - 1378

JO - Neurology

JF - Neurology

IS - 9

ER -

MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Abstract

ASJC Scopus subject areas

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