MR Imaging of blood-borne liver metastases in mice: contrast enhancement with Fe-EHPG

Faina Shtern, Leoncio Garrido, Carolyn Compton, Joseph K. Swiniarski, Randall B. Lauffer, Thomas J. Brady

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


To determine whether iron(III)ethylenebis-(2-hydrophenylglycine) (Fe-EHPG), a prototype hepatobiliary magnetic resonance imaging agent, can enhance the liver-to-tumor contrast-to-noise ratio (C/N) in models of liver tumors in mice, two types of cell inoculation were used: intrahepatic implantation of M5076 sarcoma and intrasplenic injection of colon tumor (C-26) or M5076 sarcoma. Significant enhancement of the liver-to-tumor C/N and/or improved visualization of small lesions was consistently observed on T1-weighted images obtained after injection of the contrast material. For intrahepatic implants, the C/N on postinjection T1-weighted images was superior to that on T1- and T2-weighted preinjection images. For the C-26 metastatic liver lesions of larger diameter (>5 mm), the C/N on postinjection T1-weighted studies was superior to that on preinjection T1-weighted images but was comparable to that on preinjection T2-weighted images. However, higher C/N after administration of Fe-EHPG improved visualization of medium-sized (3-5-mm) and small (1-3-mm) metastatic lesions in both M5076 and C-26 models. These results demonstrate that MR imaging with appropriate hepatobiliary agents appears promising for early detection of liver metastases.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
Issue number1
StatePublished - Jan 1991
Externally publishedYes


  • Contrast media, experimental studies
  • Iron
  • Liver neoplasms, MR studies, 761.1214
  • Liver neoplasms, secondary, 761.332
  • Magnetic resonance (MR), contrast enhancement

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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