Mr color mapping of myelin fiber orientation

Philippe Douek, Robert Turner, James Pekar, Nicholas Patronas, Denis Le Bihan

Research output: Contribution to journalArticlepeer-review

216 Scopus citations


Diffusion of water in brain white matter has been shown to be anisotropic: Water mobility is lower when measured perpendicular to the fiber direction rather than parallel to it. This feature was used to produce images of the myelin fiber orientation. Coronal and sagittal MR diffusion images were obtained in volunteers using an echo-planar imaging sequence sensitized to molecular diffusion in perpendicular directions. Color-coded images of myelin orientation were then generated by combining these images together. The orientation of the white matter tracts was found to be in excellent agreement with known anatomy. Myelin fiber orientation mapping may offer a new perspective to evaluate white matter disorders.

Original languageEnglish (US)
Pages (from-to)923-929
Number of pages7
JournalJournal of computer assisted tomography
Issue number6
StatePublished - Nov 1991
Externally publishedYes


  • Brain
  • Diseases
  • Magnetic resonance imaging techniques
  • Myelin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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