MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!

Bruno P. Soares; Jeffrey D. Chien; Max Wintermark

doi:10.1161/STROKEAHA.108.526814

MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!

Bruno P. Soares, Jeffrey D. Chien, Max Wintermark

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery ("recanalization") and the downstream capillary blood flow ("reperfusion"). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke.

Original language	English (US)
Pages (from-to)	S24-S27
Journal	Stroke
Volume	40
Issue number	3 SUPPL. 1
DOIs	https://doi.org/10.1161/STROKEAHA.108.526814
State	Published - Mar 2009
Externally published	Yes

Keywords

Brain infarction
Brain ischemia
CT
Cerebral infarct
Magnetic resonance
Neuroradiology
Reprefusion
tPA

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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10.1161/STROKEAHA.108.526814

Cite this

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title = "MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!",

abstract = "Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery ({"}recanalization{"}) and the downstream capillary blood flow ({"}reperfusion{"}). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke.",

keywords = "Brain infarction, Brain ischemia, CT, Cerebral infarct, Magnetic resonance, Neuroradiology, Reprefusion, tPA",

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AU - Wintermark, Max

PY - 2009/3

Y1 - 2009/3

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AB - Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery ("recanalization") and the downstream capillary blood flow ("reperfusion"). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke.

KW - Brain infarction

KW - Brain ischemia

KW - CT

KW - Cerebral infarct

KW - Magnetic resonance

KW - Neuroradiology

KW - Reprefusion

KW - tPA

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MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!

Abstract

Keywords

ASJC Scopus subject areas

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