Moving in the right direction: How eukaryotic cells migrate along chemical gradients

Huaqing Cai; Peter N. Devreotes

doi:10.1016/j.semcdb.2011.07.020

Moving in the right direction: How eukaryotic cells migrate along chemical gradients

Huaqing Cai, Peter N. Devreotes

School of Medicine

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.

Original language	English (US)
Pages (from-to)	834-841
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.semcdb.2011.07.020
State	Published - Oct 2011

Keywords

Chemotaxis
Dictyostelium
LEGI
Neutrophils
PI3K
PTEN
TORC2

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2011.07.020

Cite this

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title = "Moving in the right direction: How eukaryotic cells migrate along chemical gradients",

abstract = "Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.",

keywords = "Chemotaxis, Dictyostelium, LEGI, Neutrophils, PI3K, PTEN, TORC2",

author = "Huaqing Cai and Devreotes, {Peter N.}",

note = "Funding Information: The authors wish to acknowledge members of the Devreotes lab, in particular Yulia Artemenko for allowing the inclusion of her unpublished data. We apologize to any colleagues whose work was not mentioned due to space restriction. This work is supported by National Institutes of Health grants GM28007 and GM34933 to P.N.D. and Helen Hay Whitney postdoctoral fellowship to H.C.",

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T2 - How eukaryotic cells migrate along chemical gradients

AU - Cai, Huaqing

AU - Devreotes, Peter N.

N1 - Funding Information: The authors wish to acknowledge members of the Devreotes lab, in particular Yulia Artemenko for allowing the inclusion of her unpublished data. We apologize to any colleagues whose work was not mentioned due to space restriction. This work is supported by National Institutes of Health grants GM28007 and GM34933 to P.N.D. and Helen Hay Whitney postdoctoral fellowship to H.C.

PY - 2011/10

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N2 - Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.

AB - Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.

KW - Chemotaxis

KW - Dictyostelium

KW - LEGI

KW - Neutrophils

KW - PI3K

KW - PTEN

KW - TORC2

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M3 - Review article

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AN - SCOPUS:81955162982

SN - 1084-9521

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EP - 841

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

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ER -

Moving in the right direction: How eukaryotic cells migrate along chemical gradients

Abstract

Keywords

ASJC Scopus subject areas

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