TY - JOUR
T1 - Moving from the HIV Organ Policy Equity Act to HIV Organ Policy Equity in action
T2 - Changing practice and challenging stigma
AU - Doby, Brianna L.
AU - Tobian, Aaron A.R.
AU - Segev, Dorry L.
AU - Durand, Christine M.
N1 - Funding Information:
The work was supported by the National Institutes of Health, K23CA177321-01A1 (Durand), R34AI123023 (Durand), 1R01AI120938-01A1 (Tobian), K24DK 101828 (Segev), UO1AI134591 (Durand/Segev), and Johns Hopkins University Center for AIDS Research 1P30AI094189 (Durand).
Funding Information:
Dr C.M.D. has received research grants from Bristol Meyers Squibb, Gilead Sciences, Merck Pharmaceuticals, and Viiv Healthcare. Dr C.M.D. has also served as a scientific advisor for Bristol Meyers Squibb, Gilead Sciences, and Merck Pharmaceuticals.
Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Purpose of review The HIV Organ Policy Equity (HOPE) Act, signed in 2013, reversed the federal ban on HIV-to-HIV transplantation. In this review, we examine the progress in HOPE implementation, the current status of HIV-to-HIV transplantation, and remaining challenges. Recent findings Pursuant to the HOPE Act, the Department of Health and Human Services revised federal regulations to allow HIV-to-HIV transplants under research protocols adherent to criteria published by the National Institutes of Health. The first HIV-to-HIV kidney and liver transplants were performed at Johns Hopkins in March of 2016. Legal and practical challenges remain. Further efforts are needed to educate potential HIV\+ donors and to support Organ Procurement Organizations. As of November 2017, there are 22 transplant centers approved to perform HIV-to-HIV transplants in 10 United Network for Organ Sharing regions. To date, 16 Organ Procurement Organizations in 22 states have evaluated HIV\+ donors. The National Institutes of Health-funded HOPE in Action: A Multicenter Clinical Trial of HIV-to-HIV Deceased Donor (HIVDD) Kidney Transplantation Kidney Trial will launch at 19 transplant centers in December of 2017. A HOPE in Action Multicenter HIVDD Liver Trial is in development. Summary Significant progress toward full HOPE implementation has been made though barriers remain. Some challenges are unique to HIV-HIV transplantation, whereas others are amplifications of issues across the current transplant system. In addition to a public health benefit for all transplant candidates in the United States, partnership on the HOPE Act has the potential to address systemic challenges to national donation and transplantation.
AB - Purpose of review The HIV Organ Policy Equity (HOPE) Act, signed in 2013, reversed the federal ban on HIV-to-HIV transplantation. In this review, we examine the progress in HOPE implementation, the current status of HIV-to-HIV transplantation, and remaining challenges. Recent findings Pursuant to the HOPE Act, the Department of Health and Human Services revised federal regulations to allow HIV-to-HIV transplants under research protocols adherent to criteria published by the National Institutes of Health. The first HIV-to-HIV kidney and liver transplants were performed at Johns Hopkins in March of 2016. Legal and practical challenges remain. Further efforts are needed to educate potential HIV\+ donors and to support Organ Procurement Organizations. As of November 2017, there are 22 transplant centers approved to perform HIV-to-HIV transplants in 10 United Network for Organ Sharing regions. To date, 16 Organ Procurement Organizations in 22 states have evaluated HIV\+ donors. The National Institutes of Health-funded HOPE in Action: A Multicenter Clinical Trial of HIV-to-HIV Deceased Donor (HIVDD) Kidney Transplantation Kidney Trial will launch at 19 transplant centers in December of 2017. A HOPE in Action Multicenter HIVDD Liver Trial is in development. Summary Significant progress toward full HOPE implementation has been made though barriers remain. Some challenges are unique to HIV-HIV transplantation, whereas others are amplifications of issues across the current transplant system. In addition to a public health benefit for all transplant candidates in the United States, partnership on the HOPE Act has the potential to address systemic challenges to national donation and transplantation.
KW - HIV
KW - HIV Organ Policy Equity Act
KW - HIV-infected donors
KW - Solid organ transplantation
UR - http://www.scopus.com/inward/record.url?scp=85047781982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047781982&partnerID=8YFLogxK
U2 - 10.1097/MOT.0000000000000510
DO - 10.1097/MOT.0000000000000510
M3 - Review article
C2 - 29432254
AN - SCOPUS:85047781982
SN - 1087-2418
VL - 23
SP - 271
EP - 278
JO - Current opinion in organ transplantation
JF - Current opinion in organ transplantation
IS - 2
ER -