Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner

Elina Erikson; Paul R. Wratil; Martin Frank; Ina Ambiel; Katharina Pahnke; Maria Pino; Parastoo Azadi; Nuria Izquierdo-Useros; Javier Martinez-Picado; Chris Meier; Ronald L. Schnaar; Paul R. Crocker; Werner Reutter; Oliver T. Keppler

doi:10.1074/jbc.M115.681338

Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner

Elina Erikson
, Paul R. Wratil
, Martin Frank
, Ina Ambiel
, Katharina Pahnke
, Maria Pino
, Parastoo Azadi
, Nuria Izquierdo-Useros
, Javier Martinez-Picado
, Chris Meier
, Ronald L. Schnaar
, Paul R. Crocker
, Werner Reutter
, Oliver T. Keppler

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.

Original language	English (US)
Pages (from-to)	27345-27359
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M115.681338
State	Published - Nov 6 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Erikson, E., Wratil, P. R., Frank, M., Ambiel, I., Pahnke, K., Pino, M., Azadi, P., Izquierdo-Useros, N., Martinez-Picado, J., Meier, C., Schnaar, R. L., Crocker, P. R., Reutter, W., & Keppler, O. T. (2015). Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner. Journal of Biological Chemistry, 290(45), 27345-27359. https://doi.org/10.1074/jbc.M115.681338

Erikson, E, Wratil, PR, Frank, M, Ambiel, I, Pahnke, K, Pino, M, Azadi, P, Izquierdo-Useros, N, Martinez-Picado, J, Meier, C, Schnaar, RL, Crocker, PR, Reutter, W & Keppler, OT 2015, 'Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner', Journal of Biological Chemistry, vol. 290, no. 45, pp. 27345-27359. https://doi.org/10.1074/jbc.M115.681338

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title = "Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner",

abstract = "Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.",

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AU - Ambiel, Ina

AU - Pahnke, Katharina

AU - Pino, Maria

AU - Azadi, Parastoo

AU - Izquierdo-Useros, Nuria

AU - Martinez-Picado, Javier

AU - Meier, Chris

AU - Schnaar, Ronald L.

AU - Crocker, Paul R.

AU - Reutter, Werner

AU - Keppler, Oliver T.

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AB - Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.

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Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner

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