Mouse chromosome fragility

M. M. Sanz; E. C. Jenkins; W. T. Brown; M. T. Davisson; M. J. Kevin; T. H. Roderick; W. P. Silverman; H. M. Wisniewski

doi:10.1002/ajmg.1320230141

Mouse chromosome fragility

M. M. Sanz, E. C. Jenkins, W. T. Brown, M. T. Davisson, M. J. Kevin, T. H. Roderick, W. P. Silverman, H. M. Wisniewski

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14 Scopus citations

Abstract

When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

Original language	English (US)
Pages (from-to)	491-509
Number of pages	19
Journal	American journal of medical genetics
Volume	23
Issue number	1-2
DOIs	https://doi.org/10.1002/ajmg.1320230141
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Mouse chromosome fragility",

abstract = "When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.",

author = "Sanz, {M. M.} and Jenkins, {E. C.} and Brown, {W. T.} and Davisson, {M. T.} and Kevin, {M. J.} and Roderick, {T. H.} and Silverman, {W. P.} and Wisniewski, {H. M.}",

year = "1986",

doi = "10.1002/ajmg.1320230141",

language = "English (US)",

volume = "23",

pages = "491--509",

journal = "American journal of medical genetics",

issn = "0148-7299",

publisher = "Wiley-Liss Inc.",

number = "1-2",

}

TY - JOUR

T1 - Mouse chromosome fragility

AU - Sanz, M. M.

AU - Jenkins, E. C.

AU - Brown, W. T.

AU - Davisson, M. T.

AU - Kevin, M. J.

AU - Roderick, T. H.

AU - Silverman, W. P.

AU - Wisniewski, H. M.

PY - 1986

Y1 - 1986

N2 - When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

AB - When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

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VL - 23

SP - 491

EP - 509

JO - American journal of medical genetics

JF - American journal of medical genetics

IS - 1-2

ER -

Mouse chromosome fragility

Abstract

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