Motor nerve sprouting and acetylcholine receptors

Alan Pestronk; Daniel B. Drachman

doi:10.1126/science.204007

Motor nerve sprouting and acetylcholine receptors

Alan Pestronk, Daniel B. Drachman

School of Medicine

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with α-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.

Original language	English (US)
Pages (from-to)	1223-1225
Number of pages	3
Journal	Science
Volume	199
Issue number	4334
DOIs	https://doi.org/10.1126/science.204007
State	Published - 1978

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title = "Motor nerve sprouting and acetylcholine receptors",

abstract = "Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with α-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.",

author = "Alan Pestronk and Drachman, {Daniel B.}",

year = "1978",

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language = "English (US)",

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pages = "1223--1225",

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publisher = "American Association for the Advancement of Science",

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AU - Pestronk, Alan

AU - Drachman, Daniel B.

PY - 1978

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N2 - Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with α-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.

AB - Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with α-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.

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U2 - 10.1126/science.204007

DO - 10.1126/science.204007

M3 - Article

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AN - SCOPUS:0018101453

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JO - Science

JF - Science

IS - 4334

ER -

Motor nerve sprouting and acetylcholine receptors

Abstract

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