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Motion correction algorithms for pediatric spinal cord diffusion tensor imaging

  • Devon M. Middleton
  • , Feroze B. Mohamed
  • , Nadia Barakat
  • , Louis N. Hunter
  • , Jurgen Finsterbusch
  • , Scott H. Faro
  • , Pallav Shah
  • , Amer Samdani
  • , M. J. Mulcahey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this investigation was to determine a reliable motion correction method for pediatric spinal cord diffusion tensor imaging (DTI) and show effects of motion correction on DTI parameters in normal subjects and patients with spinal cord injury (SCI). Images were corrected for motion using two types of transformation and three cost functions. Corrected images and transformations were examined quantitatively and qualitatively. FA and MD indices were calculated pre- and post-motion correction. Blinded evaluation of pre- and post-correction images showed significant improvement in corrected images (p<0.0001). Statistically significant (p=0.02) decrease in FA (14-21%) was found in post correction images for SCI subjects, while normals showed minimal FA reduction (<5%) and were not significant. Quantitative and qualitative analysis showed rigid scaled-least-squares registration to be effective and reliable.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages79-80
Number of pages2
DOIs
StatePublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
Country/TerritoryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

ASJC Scopus subject areas

  • Bioengineering

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