Mosquito immunity against arboviruses

Shuzhen Sim, Natapong Jupatanakul, George Dimopoulos

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Arthropod-borne viruses (arboviruses) pose a significant threat to global health, causing human disease with increasing geographic range and severity. The recent availability of the genome sequences of medically important mosquito species has kick-started investigations into the molecular basis of how mosquito vectors control arbovirus infection. Here, we discuss recent findings concerning the role of the mosquito immune system in antiviral defense, interactions between arboviruses and fundamental cellular processes such as apoptosis and autophagy, and arboviral suppression of mosquito defense mechanisms. This knowledge provides insights into co-evolutionary processes between vector and virus and also lays the groundwork for the development of novel arbovirus control strategies that target the mosquito vector.

Original languageEnglish (US)
Pages (from-to)4479-4504
Number of pages26
Issue number11
StatePublished - Nov 19 2014


  • Arbovirus
  • Innate immunity
  • Mosquito

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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