More is less: neurogenesis and age-related cognitive decline in Long-Evans rats.

Jennifer L. Bizon; Michela Gallagher

doi:10.1126/sageke.2005.7.re2

More is less: neurogenesis and age-related cognitive decline in Long-Evans rats.

Jennifer L. Bizon, Michela Gallagher

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

A reduction in the ability to generate new neurons in the brain has been suggested to contribute to cognitive decline with advanced age. In an outbred model strain of Long-Evans rats, cognitive performance as a function of age is variable in assessments of hippocampal-dependent spatial memory. Recent research indicates that greater hippocampal neurogenesis accompanies diminished cognitive abilities in older Long-Evans rats. These findings imply that the role of neurogenesis might change between youth and old age, and that further work is needed to understand the potential benefits and liabilities that new neurons may afford an aging brain.

Original language	English (US)
Pages (from-to)	re2
Journal	Science of aging knowledge environment : SAGE KE
Volume	2005
Issue number	7
DOIs	https://doi.org/10.1126/sageke.2005.7.re2
State	Published - Feb 16 2005
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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AB - A reduction in the ability to generate new neurons in the brain has been suggested to contribute to cognitive decline with advanced age. In an outbred model strain of Long-Evans rats, cognitive performance as a function of age is variable in assessments of hippocampal-dependent spatial memory. Recent research indicates that greater hippocampal neurogenesis accompanies diminished cognitive abilities in older Long-Evans rats. These findings imply that the role of neurogenesis might change between youth and old age, and that further work is needed to understand the potential benefits and liabilities that new neurons may afford an aging brain.

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More is less: neurogenesis and age-related cognitive decline in Long-Evans rats.

Abstract

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