More aggressive behavior of squamous cell carcinoma of the anterior tongue in young women

Hannah Vargas, Karen T. Pitman, Jonas T. Johnson, Lisa T. Galati

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Objective: To review the combined experience from two large medical centers in treating young female patients with anterior tongue cancer to determine the clinical course of this unique subset of patients. Study Design: Retrospective study. Methods: Seventeen female patients less than 40 years of age (group A) and 17 older patients, both male and female, greater than 40 years of age (group B) who had treatment for invasive squamous cell carcinoma of the anterior tongue were studied. The charts were reviewed for the clinical staging, treatment, and outcome of each patient. The disease-free survival and recurrence rates were compared between the two cohorts. Results: The mean disease stage between the groups was II. The survival analysis showed a significant difference between the two groups in recurrences (group A = 65%, group B = 41%; P = .02). Further, of the patients who had recurrence, the young women did so significantly earlier in their disease course than the older patients (group A = 14 mo, group B = 40 mo; P < .05). Although the survival differences did not reach statistical significance (P = .15), the power of the study was low (power = 0.26) resulting in a high-level type II error. Conclusion: These data suggest that young women with squamous cell carcinoma of the anterior tongue have significantly higher rates of recurrent disease and the interval to recurrence is significantly shorter than in older patients. Further investigation is warranted until a statistically significant cohort is accrued; until that time, these patients warrant an aggressive initial treatment and close surveillance for recurrence.

Original languageEnglish (US)
Pages (from-to)1623-1626
Number of pages4
Issue number10
StatePublished - 2000
Externally publishedYes


  • Recurrence
  • Survival
  • Tongue cancer
  • Young women

ASJC Scopus subject areas

  • Otorhinolaryngology


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