Monte Carlo studies of the lateral organization of molecules in two-component lipid bilayers

Ernesto Freire, Brian Snyder

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The lateral organization of two-component phosphatidylcholine bilayers has been investigated using Monte Carlo calculations based upon non-ideality parameters deduced from the phase diagrams of these mixtures. The results are used to develop a quantitative description of the distribution and spatial localization of compositional regions along the bilayer plane in both the gel and liquid crystalline phases. In particular, a detailed analysis of the physical extension (lateral connectivity) and compactness of the compositional clusters is made. It is concluded that the chemical composition of the membrane, the physical state of the bilayer and the interaction energies between molecules greatly influence the lateral connectivity and compactness of compositional regions and that these parameters might play an important role in the formation of diffusional pathways along the membrane plane.

Original languageEnglish (US)
Pages (from-to)643-654
Number of pages12
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number3
StatePublished - 1980


  • Diffusional pathway
  • Lateral organization
  • Lipid bilayer
  • Monte Carlo study
  • Phosphatidylcholine

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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