TY - JOUR
T1 - Monosynaptic activation of long descending propriospinal neurons from the lateral vestibular nucleus and the medial longitudinal fasciculus
AU - Skinner, R. D.
AU - Remmel, R. S.
AU - Minor, L. B.
N1 - Funding Information:
Abbreviations: LDP-long descending propriospinal: MLF-medial longitudinal fasciculus: LVN, MVN-lateral, medial vestibular nucleus; Nr-nucleus reticularis; VC-ventral cord; PS-propriospinal. ’ We thank Nancy Stone for typing and Gael Sammartino for technical assistance. David Borne participated in some of the experiments. Lloyd B. Minor was an extem from Brown University, Division of Biology and Medicine. His present address is Department of Surgery, Duke University School of Medicine. Durham, NC 27705. This work was sponsored by U.S. Public Health Service grant NS 10304 and by National Science Foundation grant ISP 801 1447.
PY - 1984/12
Y1 - 1984/12
N2 - In decerebrate cats long descending propriospinal (LDP) neurons were recorded extracellularly in the cervical enlargement. They were identified antidromically by spinal cord stimulation at the L1-L2 level. Inputs to these cells were tested by stimulating the medial longitudinal fasciculus (MLF) 5 to 6 mm rostral to the obex, the lateral vestibular nucleus (LVN), the upper MLF 1 mm caudal to the trochlear nucleus, and the medial vestibular nucleus (MVN), all on the ipsilateral side. Action potentials were elicited in 44% ( 64 144) of LDP neurons in the ventral horn (laminae VII, VIII) at a segmental latency of 1 ms or less following brain stem stimulation. This was considered to be a monosynaptic latency. The most effective stimulation sites were the MLF and the LVN. MLF stimulation accounted for about two-thirds of the monosynaptically elicited action potentials and LVN for about one-third. Another 22% of LDP neurons responded at longer latencies, but some of those responses may also have been monosynaptic. Stimulation of the upper MLF and the MVN were much less effective, indicating that the MLF input was predominantly from fibers originating in the medullary and/or pontine reticular formation.
AB - In decerebrate cats long descending propriospinal (LDP) neurons were recorded extracellularly in the cervical enlargement. They were identified antidromically by spinal cord stimulation at the L1-L2 level. Inputs to these cells were tested by stimulating the medial longitudinal fasciculus (MLF) 5 to 6 mm rostral to the obex, the lateral vestibular nucleus (LVN), the upper MLF 1 mm caudal to the trochlear nucleus, and the medial vestibular nucleus (MVN), all on the ipsilateral side. Action potentials were elicited in 44% ( 64 144) of LDP neurons in the ventral horn (laminae VII, VIII) at a segmental latency of 1 ms or less following brain stem stimulation. This was considered to be a monosynaptic latency. The most effective stimulation sites were the MLF and the LVN. MLF stimulation accounted for about two-thirds of the monosynaptically elicited action potentials and LVN for about one-third. Another 22% of LDP neurons responded at longer latencies, but some of those responses may also have been monosynaptic. Stimulation of the upper MLF and the MVN were much less effective, indicating that the MLF input was predominantly from fibers originating in the medullary and/or pontine reticular formation.
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U2 - 10.1016/0014-4886(84)90081-5
DO - 10.1016/0014-4886(84)90081-5
M3 - Article
C2 - 6499987
AN - SCOPUS:0021719440
SN - 0014-4886
VL - 86
SP - 462
EP - 472
JO - Experimental Neurology
JF - Experimental Neurology
IS - 3
ER -