Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats

V. V. Sherstnev; M. V. Pletnikov; Z. I. Storozheva; S. G. El'nikova; T. M. Pankova; M. V. Starostina; M. B. Shtark

doi:10.1007/bf02446918

Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats

V. V. Sherstnev, M. V. Pletnikov, Z. I. Storozheva, S. G. El'nikova, T. M. Pankova, M. V. Starostina, M. B. Shtark

Research output: Contribution to journal › Article › peer-review

Abstract

Effect of monoclonal antibodies to A3G7 protein specific for cerebellar Purkinje cells and hippocampal pyramidal neurons on learning, consolidation, and retrieval of short-and long-term habituation to acoustic startle reaction is studied in adult rats. Application of 1 mg/ml antibodies to the cerebellar vermis selectively disturbs long-term habituation, while 2 mg/ml antibodies inhibit both short- and long-term habituation. The data are analyzed with consideration of the involvement of A3G7 protein into nerve growth and neurotransmittory processes underlying learning and memory in developing and mature brain.

Original language	English (US)
Pages (from-to)	813-815
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	126
Issue number	2
DOIs	https://doi.org/10.1007/bf02446918
State	Published - Aug 1998
Externally published	Yes

Keywords

Acoustic startle reaction
Learning
Memory
Monoclonal antibodies
Nerve growth factor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/bf02446918

Cite this

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title = "Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats",

abstract = "Effect of monoclonal antibodies to A3G7 protein specific for cerebellar Purkinje cells and hippocampal pyramidal neurons on learning, consolidation, and retrieval of short-and long-term habituation to acoustic startle reaction is studied in adult rats. Application of 1 mg/ml antibodies to the cerebellar vermis selectively disturbs long-term habituation, while 2 mg/ml antibodies inhibit both short- and long-term habituation. The data are analyzed with consideration of the involvement of A3G7 protein into nerve growth and neurotransmittory processes underlying learning and memory in developing and mature brain.",

keywords = "Acoustic startle reaction, Learning, Memory, Monoclonal antibodies, Nerve growth factor",

author = "Sherstnev, {V. V.} and Pletnikov, {M. V.} and Storozheva, {Z. I.} and El'nikova, {S. G.} and Pankova, {T. M.} and Starostina, {M. V.} and Shtark, {M. B.}",

year = "1998",

month = aug,

doi = "10.1007/bf02446918",

language = "English (US)",

volume = "126",

pages = "813--815",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer",

number = "2",

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TY - JOUR

T1 - Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats

AU - Sherstnev, V. V.

AU - Pletnikov, M. V.

AU - Storozheva, Z. I.

AU - El'nikova, S. G.

AU - Pankova, T. M.

AU - Starostina, M. V.

AU - Shtark, M. B.

PY - 1998/8

Y1 - 1998/8

N2 - Effect of monoclonal antibodies to A3G7 protein specific for cerebellar Purkinje cells and hippocampal pyramidal neurons on learning, consolidation, and retrieval of short-and long-term habituation to acoustic startle reaction is studied in adult rats. Application of 1 mg/ml antibodies to the cerebellar vermis selectively disturbs long-term habituation, while 2 mg/ml antibodies inhibit both short- and long-term habituation. The data are analyzed with consideration of the involvement of A3G7 protein into nerve growth and neurotransmittory processes underlying learning and memory in developing and mature brain.

AB - Effect of monoclonal antibodies to A3G7 protein specific for cerebellar Purkinje cells and hippocampal pyramidal neurons on learning, consolidation, and retrieval of short-and long-term habituation to acoustic startle reaction is studied in adult rats. Application of 1 mg/ml antibodies to the cerebellar vermis selectively disturbs long-term habituation, while 2 mg/ml antibodies inhibit both short- and long-term habituation. The data are analyzed with consideration of the involvement of A3G7 protein into nerve growth and neurotransmittory processes underlying learning and memory in developing and mature brain.

KW - Acoustic startle reaction

KW - Learning

KW - Memory

KW - Monoclonal antibodies

KW - Nerve growth factor

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DO - 10.1007/bf02446918

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JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

IS - 2

ER -

Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats

Abstract

Keywords

ASJC Scopus subject areas

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