@article{db47ff794a8748418cc25fda02484b36,
title = "Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging",
abstract = "Schwann cell (SC)-specific monocarboxylate transporter 1 (MCT1) knockout mice were generated by mating MCT1f/f mice with myelin protein zero (P0)-Cre mice. P0-Cre+/−, MCT1f/f mice have no detectable early developmental defects, but develop hypomyelination and reduced conduction velocity in sensory, but not motor, peripheral nerves during maturation and aging. Furthermore, reduced mechanical sensitivity is evident in aged P0-Cre+/−, MCT1f/f mice. MCT1 deletion in SCs impairs both their glycolytic and mitochondrial functions, leading to altered lipid metabolism of triacylglycerides, diacylglycerides, and sphingomyelin, decreased expression of myelin-associated glycoprotein, and increased expression of c-Jun and p75-neurotrophin receptor, suggesting a regression of SCs to a less mature developmental state. Taken together, our results define the contribution of SC MCT1 to both SC metabolism and peripheral nerve maturation and aging.",
keywords = "MCT1, Schwann cell, lactate, metabolism, monocarboxylate transporter, myelination, peripheral nerve, sensory axons, triacylglycerides",
author = "Jha, {Mithilesh Kumar} and Youngjin Lee and Russell, {Katelyn A.} and Fang Yang and Dastgheyb, {Raha M.} and Pragney Deme and Ament, {Xanthe H.} and Weiran Chen and Ying Liu and Yun Guan and Polydefkis, {Michael J.} and Ahmet Hoke and Haughey, {Norman J.} and Rothstein, {Jeffrey D.} and Morrison, {Brett M.}",
note = "Funding Information: The authors would like to thank Dr. Mohamed Farah, Ms. Carol Cooke, Ms. Kimberly Brown, and the Johns Hopkins Neurology Electron Microscopy Core, for their assistance in processing and photographing electron microscopic pictures and processing embedded nerve tissue for toluidine blue staining. We also thank Dr. Ru-ching Hsia and the University of Maryland Electron Microscopy Core Imaging Facility for assistance with photographing electron microscopic pictures. We would also like to thank the Pain Research Core funded by the Blaustein Fund and the Neurosurgery Pain Research Institute at the Johns Hopkins University for providing facilities for behavioral studies. Financial support was provided by NIH-NS086818-01 (B.M.M.). Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2020",
month = jan,
day = "1",
doi = "10.1002/glia.23710",
language = "English (US)",
volume = "68",
pages = "161--177",
journal = "Glia",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "1",
}