TY - JOUR
T1 - Monkey ovarian contractility
T2 - its relationship to ovulation
AU - Virutamasen, P.
AU - Wright, K. H.
AU - Wallach, E. E.
N1 - Funding Information:
Received June 7, 1973. * Supported by The Population Council Grant M72.116. t Presented at The Twenty-Ninth Annual Meeting of The American Fertility Society, April 5-7, 1973, San Francisco, Calif. :j: Ford Foundation Fellow in Reproductive Biology. Present address: Department of Obstetrics and Gynecology, Chulalongkorn Hospital, Bangkok 5, Thailand. § Address requests for reprints to: Edward E. Wallach, M.D., Eighth and Spruce Streets, Pennsylvania Hospital, Philadelphia, Pa. 19107.
PY - 1973
Y1 - 1973
N2 - Ovarian contractility was studied in the rhesus monkey in vivo and in vitro. Spontaneous ovarian contractions were observed in all five monkeys studied in vivo. In the in vitro preparations, all six ovaries removed during the follicular phase exhibited spontaneous contractions, whereas only three of nine preparations studied in the postovulatory phase contracted spontaneously. The corpus luteum bearing ovary of a pregnant monkey failed to contract in vitro, whereas its contralateral ovary exhibited spontaneous contractility and responded to various pharmacologic agents. Of 20 other ovaries studied without the benefit of previous mentrual cycle data, 12 demonstrated spontaneous contractions. The influence of adrenergic agents (norepinephrine, isoproterenol, phenoxybenzamine, and propranolol), prostaglandins (PGE2 and PGF2α), and oxytocin on observed contractile patterns was also investigated. The observations: demonstrate that the primate ovary contracts both in vivo and in vitro; indicate that a variety of pharmacologic agents are capable of influencing this process in predictable fashion; support the possibility that ovarian contractility may play a role in the process of ovulation in the primate; and suggest that ovarian contractile patterns are related to the local hormonal status of the ovary.
AB - Ovarian contractility was studied in the rhesus monkey in vivo and in vitro. Spontaneous ovarian contractions were observed in all five monkeys studied in vivo. In the in vitro preparations, all six ovaries removed during the follicular phase exhibited spontaneous contractions, whereas only three of nine preparations studied in the postovulatory phase contracted spontaneously. The corpus luteum bearing ovary of a pregnant monkey failed to contract in vitro, whereas its contralateral ovary exhibited spontaneous contractility and responded to various pharmacologic agents. Of 20 other ovaries studied without the benefit of previous mentrual cycle data, 12 demonstrated spontaneous contractions. The influence of adrenergic agents (norepinephrine, isoproterenol, phenoxybenzamine, and propranolol), prostaglandins (PGE2 and PGF2α), and oxytocin on observed contractile patterns was also investigated. The observations: demonstrate that the primate ovary contracts both in vivo and in vitro; indicate that a variety of pharmacologic agents are capable of influencing this process in predictable fashion; support the possibility that ovarian contractility may play a role in the process of ovulation in the primate; and suggest that ovarian contractile patterns are related to the local hormonal status of the ovary.
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U2 - 10.1016/s0015-0282(16)39971-x
DO - 10.1016/s0015-0282(16)39971-x
M3 - Article
C2 - 4200432
AN - SCOPUS:0015904555
SN - 0015-0282
VL - 24
SP - 763
EP - 771
JO - Fertility and sterility
JF - Fertility and sterility
IS - 10
ER -