Monkey nucleus basalis is enriched with choline acetyltransferase

M. McKinney; R. G. Struble; D. L. Price; J. T. Coyle

doi:10.1016/0306-4522(82)90200-7

Monkey nucleus basalis is enriched with choline acetyltransferase

M. McKinney, R. G. Struble, D. L. Price, J. T. Coyle

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The nucleus basalis of Meynert, which projects directly and diffusely to the cerebral cortex, was histologically identified in Nissl- and acetylcholinesterase-stained sections of the forebrain of Rhesus monkeys. Adjacent 1 mm thick sections were microdissected in 2 mm² blocks and assayed for choline acetyltransferase activity. The results demonstrate a marked enrichment of choline acetyltransferase activity in samples containing the nucleus basalis of Meynert and strongly suggest that this nucleus is a cholinergic nucleus in the primate.

Original language	English (US)
Pages (from-to)	2363-2368
Number of pages	6
Journal	Neuroscience
Volume	7
Issue number	10
DOIs	https://doi.org/10.1016/0306-4522(82)90200-7
State	Published - Oct 1982
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0306-4522(82)90200-7

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@article{8a07a9c398884f0789fbdc98f94f7d5d,

title = "Monkey nucleus basalis is enriched with choline acetyltransferase",

abstract = "The nucleus basalis of Meynert, which projects directly and diffusely to the cerebral cortex, was histologically identified in Nissl- and acetylcholinesterase-stained sections of the forebrain of Rhesus monkeys. Adjacent 1 mm thick sections were microdissected in 2 mm2 blocks and assayed for choline acetyltransferase activity. The results demonstrate a marked enrichment of choline acetyltransferase activity in samples containing the nucleus basalis of Meynert and strongly suggest that this nucleus is a cholinergic nucleus in the primate.",

author = "M. McKinney and Struble, {R. G.} and Price, {D. L.} and Coyle, {J. T.}",

note = "Funding Information: Acknowledgements-This study was supported by USPHS grants MH 26654, MH 00125, NS 10580, NS 15721, and NS 07179 and a grant from the McKnight Foundation. The monkeys were made available by Dr L. Ewing under NICHD contract #NOl-HD-8-2805. The authors wish to thank Drs P. Whitehouse, M. DeLong, A. Clark, and J. Hedreen for helpful discussions and C. Kenyon for excellent secretarial assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1982",

month = oct,

doi = "10.1016/0306-4522(82)90200-7",

language = "English (US)",

volume = "7",

pages = "2363--2368",

journal = "Neuroscience",

issn = "0306-4522",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Monkey nucleus basalis is enriched with choline acetyltransferase

AU - McKinney, M.

AU - Struble, R. G.

AU - Price, D. L.

AU - Coyle, J. T.

N1 - Funding Information: Acknowledgements-This study was supported by USPHS grants MH 26654, MH 00125, NS 10580, NS 15721, and NS 07179 and a grant from the McKnight Foundation. The monkeys were made available by Dr L. Ewing under NICHD contract #NOl-HD-8-2805. The authors wish to thank Drs P. Whitehouse, M. DeLong, A. Clark, and J. Hedreen for helpful discussions and C. Kenyon for excellent secretarial assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1982/10

Y1 - 1982/10

N2 - The nucleus basalis of Meynert, which projects directly and diffusely to the cerebral cortex, was histologically identified in Nissl- and acetylcholinesterase-stained sections of the forebrain of Rhesus monkeys. Adjacent 1 mm thick sections were microdissected in 2 mm2 blocks and assayed for choline acetyltransferase activity. The results demonstrate a marked enrichment of choline acetyltransferase activity in samples containing the nucleus basalis of Meynert and strongly suggest that this nucleus is a cholinergic nucleus in the primate.

AB - The nucleus basalis of Meynert, which projects directly and diffusely to the cerebral cortex, was histologically identified in Nissl- and acetylcholinesterase-stained sections of the forebrain of Rhesus monkeys. Adjacent 1 mm thick sections were microdissected in 2 mm2 blocks and assayed for choline acetyltransferase activity. The results demonstrate a marked enrichment of choline acetyltransferase activity in samples containing the nucleus basalis of Meynert and strongly suggest that this nucleus is a cholinergic nucleus in the primate.

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DO - 10.1016/0306-4522(82)90200-7

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SP - 2363

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JO - Neuroscience

JF - Neuroscience

IS - 10

ER -

Monkey nucleus basalis is enriched with choline acetyltransferase

Abstract

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