Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum

Nilabh Shastri; Niranjana Nagarajan; Kristin C. Lind; Takayuki Kanaseki

doi:10.1016/j.coi.2013.11.006

Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum

Nilabh Shastri, Niranjana Nagarajan, Kristin C. Lind, Takayuki Kanaseki

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.

Original language	English (US)
Pages (from-to)	123-127
Number of pages	5
Journal	Current Opinion in Immunology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.coi.2013.11.006
State	Published - Feb 2014
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.coi.2013.11.006

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title = "Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum",

abstract = "Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.",

author = "Nilabh Shastri and Niranjana Nagarajan and Lind, {Kristin C.} and Takayuki Kanaseki",

note = "Funding Information: We are grateful to members of our laboratory, past and present whose efforts and discussions shaped the ideas expressed here. This research is supported by grants to NS from the National Institutes of Health . ",

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AU - Shastri, Nilabh

AU - Nagarajan, Niranjana

AU - Lind, Kristin C.

AU - Kanaseki, Takayuki

N1 - Funding Information: We are grateful to members of our laboratory, past and present whose efforts and discussions shaped the ideas expressed here. This research is supported by grants to NS from the National Institutes of Health .

PY - 2014/2

Y1 - 2014/2

N2 - Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.

AB - Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.

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JF - Current Opinion in Immunology

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Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum

Abstract

ASJC Scopus subject areas

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