TY - JOUR
T1 - Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum
AU - Shastri, Nilabh
AU - Nagarajan, Niranjana
AU - Lind, Kristin C.
AU - Kanaseki, Takayuki
N1 - Funding Information:
We are grateful to members of our laboratory, past and present whose efforts and discussions shaped the ideas expressed here. This research is supported by grants to NS from the National Institutes of Health .
PY - 2014/2
Y1 - 2014/2
N2 - Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.
AB - Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.
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U2 - 10.1016/j.coi.2013.11.006
DO - 10.1016/j.coi.2013.11.006
M3 - Review article
C2 - 24556408
AN - SCOPUS:84890047365
SN - 0952-7915
VL - 26
SP - 123
EP - 127
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -