Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation

Jon R. Lorsch; Thomas E. Dever

doi:10.1074/jbc.R110.119743

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation

Jon R. Lorsch, Thomas E. Dever

Research output: Contribution to journal › Short survey › peer-review

66 Scopus citations

Abstract

A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

Original language	English (US)
Pages (from-to)	21203-21207
Number of pages	5
Journal	Journal of Biological Chemistry
Volume	285
Issue number	28
DOIs	https://doi.org/10.1074/jbc.R110.119743
State	Published - Jul 9 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.R110.119743

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abstract = "A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.",

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AU - Dever, Thomas E.

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AB - A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

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Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation

Abstract

ASJC Scopus subject areas

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