Molecular tools unveil distinct waves of ADP-ribosylation during DNA repair

Morgan Dasovich; Anthony K.L. Leung

doi:10.1016/j.crmeth.2023.100484

Molecular tools unveil distinct waves of ADP-ribosylation during DNA repair

Morgan Dasovich, Anthony K.L. Leung

Bloomberg School of Public Health

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

ADP-ribosylation is a complex post-translation modification involved in DNA repair. In a recent Molecular Cell publication, Longarini and colleagues measured ADP-ribosylation dynamics with unprecedented specificity, revealing how the monomeric and polymeric forms of ADP-ribosylation regulate the timing of DNA repair events following strand breaks.

Original language	English (US)
Article number	100484
Journal	Cell Reports Methods
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/j.crmeth.2023.100484
State	Published - May 22 2023

ASJC Scopus subject areas

Biotechnology
Biochemistry
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Genetics
Radiology Nuclear Medicine and imaging
Computer Science Applications

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10.1016/j.crmeth.2023.100484

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abstract = "ADP-ribosylation is a complex post-translation modification involved in DNA repair. In a recent Molecular Cell publication, Longarini and colleagues measured ADP-ribosylation dynamics with unprecedented specificity, revealing how the monomeric and polymeric forms of ADP-ribosylation regulate the timing of DNA repair events following strand breaks.",

author = "Morgan Dasovich and Leung, {Anthony K.L.}",

note = "Funding Information: The ADP-ribosylation work in the Leung Lab has been supported by Catalyst Award, Discovery Award, and COVID-19 Pre-Clinical Research Discovery Fund from the Johns Hopkins University as well as NIH grants T32GM080189 , R01GM104135 , and RF1AG071326 . Publisher Copyright: {\textcopyright} 2023 The Authors",

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AU - Leung, Anthony K.L.

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Y1 - 2023/5/22

N2 - ADP-ribosylation is a complex post-translation modification involved in DNA repair. In a recent Molecular Cell publication, Longarini and colleagues measured ADP-ribosylation dynamics with unprecedented specificity, revealing how the monomeric and polymeric forms of ADP-ribosylation regulate the timing of DNA repair events following strand breaks.

AB - ADP-ribosylation is a complex post-translation modification involved in DNA repair. In a recent Molecular Cell publication, Longarini and colleagues measured ADP-ribosylation dynamics with unprecedented specificity, revealing how the monomeric and polymeric forms of ADP-ribosylation regulate the timing of DNA repair events following strand breaks.

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Molecular tools unveil distinct waves of ADP-ribosylation during DNA repair

Abstract

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