Molecular techniques and genetic alterations in head and neck cancer

Patrick K. Ha, Steven S. Chang, Chad A. Glazer, Joseph A. Califano, David Sidransky

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now have a better understanding of the molecular complexity of HNSCC, but there is still much research to be done. In this review, we discuss the well described genetic alterations and touch on the newer findings, as well as some of the future directions of head and neck cancer research.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalOral Oncology
Issue number4-5
StatePublished - Apr 2009


  • DNA
  • Head and neck cancer
  • Molecular
  • Oral cancer

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research


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