TY - JOUR
T1 - Molecular profiling and targeted therapy in pediatric gliomas
T2 - Review and consensus recommendations
AU - Miklja, Zachary
AU - Pasternak, Amy
AU - Stallard, Stefanie
AU - Nicolaides, Theodore
AU - Kline-Nunnally, Cassie
AU - Cole, Bonnie
AU - Beroukhim, Rameen
AU - Bandopadhayay, Pratiti
AU - Chi, Susan
AU - Ramkissoon, Shakti H.
AU - Mullan, Brendan
AU - Bruzek, Amy K.
AU - Gauthier, Angela
AU - Garcia, Taylor
AU - Atchison, Christie
AU - Marini, Bernard
AU - Fouladi, Maryam
AU - Parsons, D. William
AU - Leary, Sarah
AU - Mueller, Sabine
AU - Ligon, Keith L.
AU - Koschmann, Carl
N1 - Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2019/8/1
Y1 - 2019/8/1
N2 - As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.
AB - As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.
KW - high-grade glioma
KW - low-grade glioma
KW - next-generation sequencing
KW - pediatric
KW - precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85078154013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078154013&partnerID=8YFLogxK
U2 - 10.1093/neuonc/noz022
DO - 10.1093/neuonc/noz022
M3 - Article
C2 - 30805642
AN - SCOPUS:85078154013
SN - 1522-8517
VL - 21
SP - 968
EP - 980
JO - Neuro-oncology
JF - Neuro-oncology
IS - 8
ER -