Molecular profiling and targeted therapy in pediatric gliomas: Review and consensus recommendations

Zachary Miklja; Amy Pasternak; Stefanie Stallard; Theodore Nicolaides; Cassie Kline-Nunnally; Bonnie Cole; Rameen Beroukhim; Pratiti Bandopadhayay; Susan Chi; Shakti H. Ramkissoon; Brendan Mullan; Amy K. Bruzek; Angela Gauthier; Taylor Garcia; Christie Atchison; Bernard Marini; Maryam Fouladi; D. William Parsons; Sarah Leary; Sabine Mueller; Keith L. Ligon; Carl Koschmann

doi:10.1093/neuonc/noz022

Molecular profiling and targeted therapy in pediatric gliomas: Review and consensus recommendations

Zachary Miklja, Amy Pasternak, Stefanie Stallard, Theodore Nicolaides, Cassie Kline-Nunnally, Bonnie Cole, Rameen Beroukhim, Pratiti Bandopadhayay, Susan Chi, Shakti H. Ramkissoon, Brendan Mullan, Amy K. Bruzek, Angela Gauthier, Taylor Garcia, Christie Atchison, Bernard Marini, Maryam Fouladi, D. William Parsons, Sarah Leary, Sabine MuellerKeith L. Ligon, Carl Koschmann

Research output: Contribution to journal › Article › peer-review

Abstract

As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.

Original language	English (US)
Pages (from-to)	968-980
Number of pages	13
Journal	Neuro-oncology
Volume	21
Issue number	8
DOIs	https://doi.org/10.1093/neuonc/noz022
State	Published - Aug 1 2019
Externally published	Yes

Keywords

high-grade glioma
low-grade glioma
next-generation sequencing
pediatric
precision medicine

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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10.1093/neuonc/noz022

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Miklja, Z., Pasternak, A., Stallard, S., Nicolaides, T., Kline-Nunnally, C., Cole, B., Beroukhim, R., Bandopadhayay, P., Chi, S., Ramkissoon, S. H., Mullan, B., Bruzek, A. K., Gauthier, A., Garcia, T., Atchison, C., Marini, B., Fouladi, M., Parsons, D. W., Leary, S., ... Koschmann, C. (2019). Molecular profiling and targeted therapy in pediatric gliomas: Review and consensus recommendations. Neuro-oncology, 21(8), 968-980. https://doi.org/10.1093/neuonc/noz022

Miklja, Z, Pasternak, A, Stallard, S, Nicolaides, T, Kline-Nunnally, C, Cole, B, Beroukhim, R, Bandopadhayay, P, Chi, S, Ramkissoon, SH, Mullan, B, Bruzek, AK, Gauthier, A, Garcia, T, Atchison, C, Marini, B, Fouladi, M, Parsons, DW, Leary, S, Mueller, S, Ligon, KL & Koschmann, C 2019, 'Molecular profiling and targeted therapy in pediatric gliomas: Review and consensus recommendations', Neuro-oncology, vol. 21, no. 8, pp. 968-980. https://doi.org/10.1093/neuonc/noz022

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abstract = "As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.",

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author = "Zachary Miklja and Amy Pasternak and Stefanie Stallard and Theodore Nicolaides and Cassie Kline-Nunnally and Bonnie Cole and Rameen Beroukhim and Pratiti Bandopadhayay and Susan Chi and Ramkissoon, {Shakti H.} and Brendan Mullan and Bruzek, {Amy K.} and Angela Gauthier and Taylor Garcia and Christie Atchison and Bernard Marini and Maryam Fouladi and Parsons, {D. William} and Sarah Leary and Sabine Mueller and Ligon, {Keith L.} and Carl Koschmann",

note = "Funding Information: CK is supported by NIH/NINDS grant K08-NS099427–01, Michigan Medicine Department of Pediatrics Gorman Scholar Award, the University of Michigan Chad Carr Pediatric Brain Tumor Center, the Chad Tough Foundation, and Hyundai Hope on Wheels. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

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doi = "10.1093/neuonc/noz022",

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AU - Miklja, Zachary

AU - Pasternak, Amy

AU - Stallard, Stefanie

AU - Nicolaides, Theodore

AU - Kline-Nunnally, Cassie

AU - Cole, Bonnie

AU - Beroukhim, Rameen

AU - Bandopadhayay, Pratiti

AU - Chi, Susan

AU - Ramkissoon, Shakti H.

AU - Mullan, Brendan

AU - Bruzek, Amy K.

AU - Gauthier, Angela

AU - Garcia, Taylor

AU - Atchison, Christie

AU - Marini, Bernard

AU - Fouladi, Maryam

AU - Parsons, D. William

AU - Leary, Sarah

AU - Mueller, Sabine

AU - Ligon, Keith L.

AU - Koschmann, Carl

N1 - Funding Information: CK is supported by NIH/NINDS grant K08-NS099427–01, Michigan Medicine Department of Pediatrics Gorman Scholar Award, the University of Michigan Chad Carr Pediatric Brain Tumor Center, the Chad Tough Foundation, and Hyundai Hope on Wheels. Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.

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Molecular profiling and targeted therapy in pediatric gliomas: Review and consensus recommendations

Abstract

Keywords

ASJC Scopus subject areas

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