Molecular predictors of EGFR-TKI sensitivity in advanced non-small cell lung cancer

Xiaozhu Zhang, Alex Chang

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non-small cell lung cancers (NSCLC) and is a major target for new therapies. Specific EGFR tyrosine kinase inhibitors (TKIs) have been developed and used for the treatment of advanced NSCLC. The clinical response, however, varies dramatically among different patient cohorts. Females, East Asians, non-smokers, and patients with adenocarcinoma usually show higher response rates. Meanwhile, a number of biological factors are also associated with EGFR-TKIs responsiveness. In order to better understand the predictive value of these biomarkers and their significance in clinical application we prepared this brief review. Here we mainly focused on EGFR somatic mutations, MET amplification, K-ras mutations, EGFRvIII mutation, EGFR gene dosage and expression, HER2 gene dosage and expression, and Akt phosphorylation. We think EGFR somatic mutation probably is the most effective molecular predictor for EGFR-TKIs responsiveness and efficacy. Mutation screening test can provide the most direct and valuable guidance for clinicians to make decision on EGFR-TKIs therapy.

Original languageEnglish (US)
Pages (from-to)209-217
Number of pages9
JournalInternational journal of medical sciences
Issue number4
StatePublished - Jul 11 2008


  • EGFR
  • Gene amplification
  • Non-small cell lung cancer
  • Somatic mutation
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • General Medicine


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