Abstract
Isoprostanes are marker of lipid peroxidation and are produced after free-radical attack of membrane lipids. In addition, they are biologically active and are essentially vaso- and broncho-constrictor. Their smooth muscle constrictor actions are closely linked to the activation of the thromboxane A2 receptor, but also involve a distinct receptor not yet identified. The response of vascular smooth muscle to isoprostanes is subclass-specific (F-series versus E-series isoprostanes) and cell- and species-related. In this review, we will address the vascular actions of isoprostanes and their possible role in vascular physiology and pathophysiology.
Original language | English (US) |
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Pages (from-to) | 69-73 |
Number of pages | 5 |
Journal | Chemistry and Physics of Lipids |
Volume | 128 |
Issue number | 1-2 |
DOIs | |
State | Published - Mar 2004 |
Externally published | Yes |
Keywords
- Constriction
- Isoprostanes
- Platelet
- Signaling
- Vascular cells
ASJC Scopus subject areas
- Biochemistry
- Biophysics