Molecular pathways in pancreatic carcinogenesis

Anne M. MacGregor-Das; Christine A. Iacobuzio-Donahue

doi:10.1002/jso.23213

Molecular pathways in pancreatic carcinogenesis

Anne M. MacGregor-Das, Christine A. Iacobuzio-Donahue

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors. J. Surg. Oncol. 2013;107:8-14.

Original language	English (US)
Pages (from-to)	8-14
Number of pages	7
Journal	Journal of Surgical Oncology
Volume	107
Issue number	1
DOIs	https://doi.org/10.1002/jso.23213
State	Published - Jan 2013
Externally published	Yes

Keywords

GNAS
RNF43
cystic neoplasm
pancreatic cancer

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.23213

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abstract = "Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors. J. Surg. Oncol. 2013;107:8-14.",

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AB - Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors. J. Surg. Oncol. 2013;107:8-14.

KW - GNAS

KW - RNF43

KW - cystic neoplasm

KW - pancreatic cancer

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Molecular pathways in pancreatic carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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