Molecular pathology of pancreatic cancer precursor lesions

Lodewijk A A Brosens, G. Johan Offerhaus

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related death in the USA. Each year about 44,000 patients are newly diagnosed with pancreatic cancer in the USA. Most of these patients present with advanced disease and have a very poor prognosis. Given this dismal prognosis, the challenge is to identify pancreatic cancer in an early stage or, better, patients at risk for pancreatic cancer before an incurable invasive carcinoma has developed. Several distinctive precursor lesions of pancreatic cancer are now known, which theoretically allows for detection of patients at risk of developing pancreatic cancer. These precursor lesions are the microscopic pancreatic intraepithelial neoplasia (PanIN) and the macroscopic cystic precursor lesions intraductal papillary mucinous neoplasia (IPMN), intraductal tubulopapillary neoplasm (ITPN), and mucinous cystic neoplasia/mucinous cystadenoma (MCN). Insight in the molecular biology of pancreatic adenocarcinoma and these precursor lesions has substantially increased during the past decades. Accurate understanding of the successive molecular genetic alterations in these lesions may eventually lead to biomarkers that can predict biological behavior and guide treatment of patients at risk of invasive pancreatic cancer. This chapter reviews the clinical, diagnostic, and molecular genetic aspects of these pancreatic cancer precursor lesions.

Original languageEnglish (US)
Title of host publicationMolecular Genetics of Pancreatic Cancer
PublisherSpringer New York
Pages27-47
Number of pages21
Volume9781461465492
ISBN (Print)9781461465492, 1461465486, 9781461465485
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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