TY - JOUR
T1 - Molecular pathogenesis of pancreatic cancer
AU - Maitra, Anirban
AU - Kern, Scott E.
AU - Hruban, Ralph H.
PY - 2006/4
Y1 - 2006/4
N2 - Pancreatic cancer is fundamentally a disease of inherited and acquired mutations in cancer-related genes. The genes targeted in pancreatic cancer include tumor-suppressor genes (p16/CDKN2A, TP53 and SMAD4), oncogenes (KRAS, BRAF, AKT2, MYB, and AIB1), and genome-maintenance genes (MLH1, MSH2, BRAC2 and other Fanconi anemia genes). An understanding of the cancer-related genes that are altered in pancreatic cancer has a number of clinical applications including genetic counseling for individuals with a family history of cancer, early detection of pancreatic neoplasia, and mechanism-based therapies for patients with advanced disease. This chapter will provide an overview of the molecular pathogenesis of pancreatic cancer with emphasis on clinical applications.
AB - Pancreatic cancer is fundamentally a disease of inherited and acquired mutations in cancer-related genes. The genes targeted in pancreatic cancer include tumor-suppressor genes (p16/CDKN2A, TP53 and SMAD4), oncogenes (KRAS, BRAF, AKT2, MYB, and AIB1), and genome-maintenance genes (MLH1, MSH2, BRAC2 and other Fanconi anemia genes). An understanding of the cancer-related genes that are altered in pancreatic cancer has a number of clinical applications including genetic counseling for individuals with a family history of cancer, early detection of pancreatic neoplasia, and mechanism-based therapies for patients with advanced disease. This chapter will provide an overview of the molecular pathogenesis of pancreatic cancer with emphasis on clinical applications.
KW - Familial aggregation
KW - Oncogene
KW - Pancreatic cancer
KW - Screening
KW - Treatment
KW - Tumor-suppressor gene
UR - http://www.scopus.com/inward/record.url?scp=33645050942&partnerID=8YFLogxK
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U2 - 10.1016/j.bpg.2005.10.002
DO - 10.1016/j.bpg.2005.10.002
M3 - Article
C2 - 16549325
AN - SCOPUS:33645050942
SN - 1521-6918
VL - 20
SP - 211
EP - 226
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
IS - 2
ER -