Molecular Mechanisms of Polarized Protein Trafficking in Epithelial Cells

Bernardo Ortega; Paul A. Welling

doi:10.1016/B978-0-12-809954-4.00045-1

Molecular Mechanisms of Polarized Protein Trafficking in Epithelial Cells

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The transport functions of epithelial cells in the gastrointestinal (GI) tract, and elsewhere, are made possible by their remarkable apical-basolateral plasma membrane asymmetry. This property, commonly called membrane polarity, is achieved by a combination of intracellular trafficking operations, including sorting, vectorial delivery and membrane-specific docking, fusion and retention mechanisms. Here we provide a review of this rapidly evolving research field within a historically relevant context.

Original language	English (US)
Title of host publication	Physiology of the Gastrointestinal Tract, Sixth Edition
Publisher	Elsevier
Pages	1027-1050
Number of pages	24
Volume	2
ISBN (Electronic)	9780128099544
ISBN (Print)	9780128124260
DOIs	https://doi.org/10.1016/B978-0-12-809954-4.00045-1
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Adaptins
Epithelial polarity
Protein sorting
Rab GTPases
SNARES
Sorting signals

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-809954-4.00045-1

Cite this

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KW - Epithelial polarity

KW - Protein sorting

KW - Rab GTPases

KW - SNARES

KW - Sorting signals

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BT - Physiology of the Gastrointestinal Tract, Sixth Edition

PB - Elsevier

ER -

Molecular Mechanisms of Polarized Protein Trafficking in Epithelial Cells

Abstract

Keywords

ASJC Scopus subject areas

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