TY - JOUR
T1 - Molecular mechanisms of optic vesicle development
T2 - Complexities, ambiguities and controversies
AU - Adler, Ruben
AU - Canto-Soler, M. Valeria
N1 - Funding Information:
Work in the authors' laboratory has been supported by NIH grants EY 04859 and Core Grant EY 1765, by an unrestricted departmental grant from Research to Prevent Blindness, Inc (New York, New York), by the Knights of Templar, and by a contribution from the William Weiss Endowment for Research. RA is the Arnall Patz Distinguished Professor of Ophthalmology. The authors are grateful to Dr Teri Belecky-Adams for the figure used as a basis for Fig. 2 , and to Ms Jane Cione for secretarial assistance.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Optic vesicle formation, transformation into an optic cup and integration with neighboring tissues are essential for normal eye formation, and involve the coordinated occurrence of complex cellular and molecular events. Perhaps not surprisingly, these complex phenomena have provided fertile ground for controversial and even contradictory results and conclusions. After presenting an overview of current knowledge of optic vesicle development, we will address conceptual and methodological issues that complicate research in this field. This will be done through a review of the pertinent literature, as well as by drawing on our own experience, gathered through recent studies of both intra- and extra-cellular regulation of optic vesicle development and patterning. Finally, and without attempting to be exhaustive, we will point out some important aspects of optic vesicle development that have not yet received enough attention.
AB - Optic vesicle formation, transformation into an optic cup and integration with neighboring tissues are essential for normal eye formation, and involve the coordinated occurrence of complex cellular and molecular events. Perhaps not surprisingly, these complex phenomena have provided fertile ground for controversial and even contradictory results and conclusions. After presenting an overview of current knowledge of optic vesicle development, we will address conceptual and methodological issues that complicate research in this field. This will be done through a review of the pertinent literature, as well as by drawing on our own experience, gathered through recent studies of both intra- and extra-cellular regulation of optic vesicle development and patterning. Finally, and without attempting to be exhaustive, we will point out some important aspects of optic vesicle development that have not yet received enough attention.
KW - Epigenetic mechanisms
KW - Extracellular signaling molecules
KW - Eye development
KW - Lens induction
KW - Morphogenetic mechanisms
KW - Optic cup
KW - Optic vesicle
KW - Pattern formation
KW - Retina development
KW - Retinal pigment epithelium
KW - Transcription factors
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U2 - 10.1016/j.ydbio.2007.01.045
DO - 10.1016/j.ydbio.2007.01.045
M3 - Review article
C2 - 17335797
AN - SCOPUS:34247101182
SN - 0012-1606
VL - 305
SP - 1
EP - 13
JO - Developmental biology
JF - Developmental biology
IS - 1
ER -