Molecular mechanisms of optic vesicle development: Complexities, ambiguities and controversies

Ruben Adler, M. Valeria Canto-Soler

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Optic vesicle formation, transformation into an optic cup and integration with neighboring tissues are essential for normal eye formation, and involve the coordinated occurrence of complex cellular and molecular events. Perhaps not surprisingly, these complex phenomena have provided fertile ground for controversial and even contradictory results and conclusions. After presenting an overview of current knowledge of optic vesicle development, we will address conceptual and methodological issues that complicate research in this field. This will be done through a review of the pertinent literature, as well as by drawing on our own experience, gathered through recent studies of both intra- and extra-cellular regulation of optic vesicle development and patterning. Finally, and without attempting to be exhaustive, we will point out some important aspects of optic vesicle development that have not yet received enough attention.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalDevelopmental biology
Issue number1
StatePublished - May 1 2007
Externally publishedYes


  • Epigenetic mechanisms
  • Extracellular signaling molecules
  • Eye development
  • Lens induction
  • Morphogenetic mechanisms
  • Optic cup
  • Optic vesicle
  • Pattern formation
  • Retina development
  • Retinal pigment epithelium
  • Transcription factors

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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