Molecular mechanisms of glutamate receptor clustering at excitatory synapses

Richard J. O'Brien, Lit Fui Lau, Richard L. Huganir

Research output: Contribution to journalArticlepeer-review

238 Scopus citations


The targeting of AMPA- and NMDA-type glutamate receptors to synapses in the central nervous system is essential for efficient excitatory synaptic transmission. Recent studies have indicated that protein-protein interactions of these receptors with synaptic proteins that contain PDZ domains are crucial for receptor targeting. NMDA receptors have been found to bind to the PSD-95 family of proteins, whereas AMPA receptors interact with the PDZ-domain-containing protein GRIP (glutamate receptor interacting protein). PSD-95 and GRIP contain multiple PDZ domains as well as other protein-protein interaction motifs that help to form large macromolecular complexes that may be important for the formation and plasticity of synapses.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1998

ASJC Scopus subject areas

  • Neuroscience(all)


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