Molecular mechanisms in neuronal and axonal apoptosis and necrosis

This article discusses the various mechanisms, biochemical pathways, and chemical substances involved in neuronal cell death and cell survival, in an attempt to put an order to the sequence of events that ultimately lead to a commitment to neurological cell death. An understanding of these pathways is crucial to discovering etiologies involved in the pathologic changes that occur in patients with multiple sclerosis and the development of therapeutic interventions.