Molecular mechanisms for lineage commitment in T cell development

E. A. Robey, B. J. Fowlkes, D. M. Pardoll

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalSeminars in immunology
Issue number1
StatePublished - Dec 1 1990


  • CD4/CD8
  • Positive selection
  • T cell development
  • T cell lineages
  • T cell receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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