Molecular mechanisms driving respiratory syncytial virus assembly

Fyza Y. Shaikh, James E. Crowe

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Respiratory syncytial virus is a single-stranded RNA virus in the Paramyxoviridae family that preferentially assembles and buds from the apical surface of polarized epithelial cells, forming filamentous structures that contain both viral proteins and the genomic RNA. Recent studies have described both viral and host factors that are involved in ribonucleoprotein assembly and trafficking of viral proteins to the cell surface. At the cell surface, viral proteins assemble into filaments that probably require interactions between viral proteins, host proteins and the cell membrane. Finally, a membrane scission event must occur to release the free virion. This article will review the recent literature describing the mechanisms that drive respiratory syncytial virus assembly and budding.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalFuture microbiology
Volume8
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • fusion proteins
  • paramyxovirus
  • respiratory syncytial viruses
  • virus assembly
  • virus filaments

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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