Molecular marker expression in oral and oropharyngeal squamous cell carcinoma

Benjamin D. Smith, Grace L. Smith, Darryl Carter, Michael P. DiGiovanna, Katherine M. Kasowitz, Clarence T. Sasaki, Bruce G. Haffty

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Objective: To determine the relative prognostic value of p53, cyclin D1, epidermal growth factor receptor (EGFR), and vascular endothelial growth factor (VEGF) expression in patients with oral and oropharyngeal squamous cell carcinoma. Design: Retrospective cohort study. Patients: Fifty-six patients with oral and oropharyngeal squamous cell carcinoma referred to the Department of Therapeutic Radiology at Yale-New Haven Hospital (Conn) between 1981 and 1992 who were treated with gross total surgical resection and postoperative external beam radiotherapy. Results: Archival tumor tissue was stained with monoclonal antibodies directed against these 4 oncoproteins and scored for staining intensity and percent distribution by a pathologist blinded to the patients' clinical outcomes. Frequency of marker expression was 48% for p53, 20% for cyclin D1, 64% for EGFR, and 41% for VEGF. In multivariate analysis, EGFR positivity was protective against locoregional relapse (relative risk [RR], 0.27; 95% confidence interval [C1], 0.11-0.66; P=.002). In contrast, advanced N stage predicted poor locoregional relapse-free survival (RR, 1.94; 95% CI, 1.03-3.66; P=.04). Predictors of poor overall survival in multivariate analysis included VEGF positivity (RR, 3.53; 95% CI, 1.75-7.13; P

Original languageEnglish (US)
Pages (from-to)780-785
Number of pages6
JournalArchives of Otolaryngology--Head and Neck Surgery
Issue number7
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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