Molecular magnetic resonance imaging in cancer

Mohammad Haris, Santosh K. Yadav, Arshi Rizwan, Anup Singh, Ena Wang, Hari Hariharan, Ravinder Reddy, Francesco M. Marincola

Research output: Contribution to journalReview articlepeer-review

Abstract

The ability to identify key biomolecules and molecular changes associated with cancer malignancy and the capacity to monitor the therapeutic outcome against these targets is critically important for cancer treatment. Recent developments in molecular imaging based on magnetic resonance (MR) techniques have provided researchers and clinicians with new tools to improve most facets of cancer care. Molecular imaging is broadly described as imaging techniques used to detect molecular signature at the cellular and gene expression levels. This article reviews both established and emerging molecular MR techniques in oncology and discusses the potential of these techniques in improving the clinical cancer care. It also discusses how molecular MR, in conjunction with other structural and functional MR imaging techniques, paves the way for developing tailored treatment strategies to enhance cancer care.

Original languageEnglish (US)
Article number313
JournalJournal of translational medicine
Volume13
Issue number1
DOIs
StatePublished - Sep 23 2015
Externally publishedYes

Keywords

  • Cancer
  • Cancer immunotherapy
  • Chemical exchange saturation transfer (CEST) imaging
  • Hyperpolarization
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Reporter genes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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