Molecular genetics of human prostate cancer

Mark A. Rubin; Angelo M. De Marzo

doi:10.1038/modpathol.3800051

Molecular genetics of human prostate cancer

Mark A. Rubin, Angelo M. De Marzo

Johns Hopkins Hospital

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Multiple factors contribute to the high Incidence and prevalence of prostate cancer Including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.

Original language	English (US)
Pages (from-to)	380-388
Number of pages	9
Journal	Modern Pathology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1038/modpathol.3800051
State	Published - Mar 2004

Keywords

Androgen receptor
Hereditary prostate cancer
Microarray
Molecular genetics
Prostate cancer
Review

ASJC Scopus subject areas

General Medicine

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10.1038/modpathol.3800051

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title = "Molecular genetics of human prostate cancer",

abstract = "Multiple factors contribute to the high Incidence and prevalence of prostate cancer Including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.",

keywords = "Androgen receptor, Hereditary prostate cancer, Microarray, Molecular genetics, Prostate cancer, Review",

author = "Rubin, {Mark A.} and {De Marzo}, {Angelo M.}",

note = "Funding Information: We thank Allan Meeker for providing us with Figure 2 for this review. This work was supported by the Specialized Program of Research Excellence for Prostate Cancer (S.P.O.R.E.) NCI Grant P50CA69568",

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AU - De Marzo, Angelo M.

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N2 - Multiple factors contribute to the high Incidence and prevalence of prostate cancer Including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.

AB - Multiple factors contribute to the high Incidence and prevalence of prostate cancer Including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.

KW - Androgen receptor

KW - Hereditary prostate cancer

KW - Microarray

KW - Molecular genetics

KW - Prostate cancer

KW - Review

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Molecular genetics of human prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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