Molecular genetics of head and neck cancer

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Head and neck cancers arise and progress through specific genetic alterations. Elucidation of these genetic changes has led to the development of a preliminary molecular progression model. Critical oncogenes and areas of chromosomal loss have been identified in a high proportion of squamous cell carcinomas. Oncogene mutations have given insight into the origin of these neoplasms and the fundamental cellular pathways that must be altered for progression. Further characterization of these genetic alterations will lead to improved molecular assays with important implications for diagnosis, prognosis, and therapy.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalCurrent opinion in oncology
Issue number3
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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