Molecular genetics of exocrine pancreatic neoplasms

S. A. Hahn; S. E. Kern

doi:10.1016/S0039-6109(16)46732-0

Molecular genetics of exocrine pancreatic neoplasms

S. A. Hahn, S. E. Kern

School of Medicine

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Molecular genetic studies of pancreatic ductal adenocarcinoma have revealed the common co-existence of K-ras, p53, and MTS1 mutations. The finding of K-ras mutations in epithelial lesions of ducts suggests them as a precursor intraepithelial neoplasm. The clinical importance of this line of work can only be anticipated at present, and a fuller understanding of genetic alterations in these neoplasms is necessary.

Original language	English (US)
Pages (from-to)	857-869
Number of pages	13
Journal	Surgical Clinics of North America
Volume	75
Issue number	5
DOIs	https://doi.org/10.1016/S0039-6109(16)46732-0
State	Published - 1995

ASJC Scopus subject areas

Surgery

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title = "Molecular genetics of exocrine pancreatic neoplasms",

abstract = "Molecular genetic studies of pancreatic ductal adenocarcinoma have revealed the common co-existence of K-ras, p53, and MTS1 mutations. The finding of K-ras mutations in epithelial lesions of ducts suggests them as a precursor intraepithelial neoplasm. The clinical importance of this line of work can only be anticipated at present, and a fuller understanding of genetic alterations in these neoplasms is necessary.",

author = "Hahn, {S. A.} and Kern, {S. E.}",

note = "Funding Information: This work was supported by NIH grant CA62924 and by Deutschen Krebshilfe. Dr. Kern is a McDonnell Foundation Scholar.",

year = "1995",

doi = "10.1016/S0039-6109(16)46732-0",

language = "English (US)",

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pages = "857--869",

journal = "Surgical Clinics of North America",

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T1 - Molecular genetics of exocrine pancreatic neoplasms

AU - Hahn, S. A.

AU - Kern, S. E.

N1 - Funding Information: This work was supported by NIH grant CA62924 and by Deutschen Krebshilfe. Dr. Kern is a McDonnell Foundation Scholar.

PY - 1995

Y1 - 1995

N2 - Molecular genetic studies of pancreatic ductal adenocarcinoma have revealed the common co-existence of K-ras, p53, and MTS1 mutations. The finding of K-ras mutations in epithelial lesions of ducts suggests them as a precursor intraepithelial neoplasm. The clinical importance of this line of work can only be anticipated at present, and a fuller understanding of genetic alterations in these neoplasms is necessary.

AB - Molecular genetic studies of pancreatic ductal adenocarcinoma have revealed the common co-existence of K-ras, p53, and MTS1 mutations. The finding of K-ras mutations in epithelial lesions of ducts suggests them as a precursor intraepithelial neoplasm. The clinical importance of this line of work can only be anticipated at present, and a fuller understanding of genetic alterations in these neoplasms is necessary.

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AN - SCOPUS:0029132150

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JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 5

ER -

Molecular genetics of exocrine pancreatic neoplasms

Abstract

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