Molecular genetic alterations in ductal pancreatic adenocarcinomas

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Pancreatic ductal adenocarcinomas are known to harbor a distinct variety of genetic alterations in oncogenes, tumor-suppressor genes, and occasionally genes that carry out DNA mismatch repair. Although this malignancy occurs at an elevated frequency in patients with familial recurrent acute pancreatitis, the genetic alterations of these particular tumors have not been reported. The changes are likely to be similar to those of sporadic pancreatic cancer; if so, this would provide useful clues for studying the progression of early and advanced neoplasia in such pancreatitis patients to aid their clinical monitoring and provision of therapeutic recommendations.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalMedical Clinics of North America
Issue number3
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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