Molecular events implicated in brain tumor angiogenesis and invasion

David Zagzag; David R. Friedlander; Ben Margolis; Martin Grumet; Gregg L. Semenza; Hua Zhong; Jonathan W. Simons; Jocelyn Holash; Stanley J. Wiegand; George D. Yancopoulos

doi:10.1159/000028975

Molecular events implicated in brain tumor angiogenesis and invasion

David Zagzag, David R. Friedlander, Ben Margolis, Martin Grumet, Gregg L. Semenza, Hua Zhong, Jonathan W. Simons, Jocelyn Holash, Stanley J. Wiegand, George D. Yancopoulos

School of Medicine

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis. Copyright (C) 2000 S. Karger AG, Basel.

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Pediatric Neurosurgery
Volume	33
Issue number	1
DOIs	https://doi.org/10.1159/000028975
State	Published - 2000

Keywords

Angiogenesis
Angiopoietins
Focal adhesion kinase
Hypoxia inducible factor-1
Tumor infiltration

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery
Clinical Neurology

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10.1159/000028975

Cite this

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title = "Molecular events implicated in brain tumor angiogenesis and invasion",

abstract = "We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis. Copyright (C) 2000 S. Karger AG, Basel.",

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author = "David Zagzag and Friedlander, {David R.} and Ben Margolis and Martin Grumet and Semenza, {Gregg L.} and Hua Zhong and Simons, {Jonathan W.} and Jocelyn Holash and Wiegand, {Stanley J.} and Yancopoulos, {George D.}",

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T1 - Molecular events implicated in brain tumor angiogenesis and invasion

AU - Zagzag, David

AU - Friedlander, David R.

AU - Margolis, Ben

AU - Grumet, Martin

AU - Semenza, Gregg L.

AU - Zhong, Hua

AU - Simons, Jonathan W.

AU - Holash, Jocelyn

AU - Wiegand, Stanley J.

AU - Yancopoulos, George D.

PY - 2000

Y1 - 2000

N2 - We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis. Copyright (C) 2000 S. Karger AG, Basel.

AB - We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis. Copyright (C) 2000 S. Karger AG, Basel.

KW - Angiogenesis

KW - Angiopoietins

KW - Focal adhesion kinase

KW - Hypoxia inducible factor-1

KW - Tumor infiltration

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DO - 10.1159/000028975

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JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

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Molecular events implicated in brain tumor angiogenesis and invasion

Abstract

Keywords

ASJC Scopus subject areas

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