Molecular epidemiology of geographically dispersed Vibrio Cholerae, Kenya, January 2009-may 2010

Ahmed Abade Mohamed; Joseph Oundo; Samuel M. Kariuki; Hamadi I. Boga; Shanaz K. Sharif; Willis Akhwale; Jared Omolo; Anyangu S. Amwayi; David Mutonga; David Kareko; Mercy Njeru; Shan Li; Robert F. Breiman; O. Colin Stine

doi:10.3201/eid1806.111774

Molecular epidemiology of geographically dispersed Vibrio Cholerae, Kenya, January 2009-may 2010

Ahmed Abade Mohamed, Joseph Oundo, Samuel M. Kariuki, Hamadi I. Boga, Shanaz K. Sharif, Willis Akhwale, Jared Omolo, Anyangu S. Amwayi, David Mutonga, David Kareko, Mercy Njeru, Shan Li, Robert F. Breiman, O. Colin Stine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.

Original language	English (US)
Pages (from-to)	925-931
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	18
Issue number	6
DOIs	https://doi.org/10.3201/eid1806.111774
State	Published - Jun 2012
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Epidemiology

Access to Document

10.3201/eid1806.111774

Cite this

Mohamed, A. A., Oundo, J., Kariuki, S. M., Boga, H. I., Sharif, S. K., Akhwale, W., Omolo, J., Amwayi, A. S., Mutonga, D., Kareko, D., Njeru, M., Li, S., Breiman, R. F., & Colin Stine, O. (2012). Molecular epidemiology of geographically dispersed Vibrio Cholerae, Kenya, January 2009-may 2010. Emerging Infectious Diseases, 18(6), 925-931. https://doi.org/10.3201/eid1806.111774

@article{946b6774200049f49f2ef9fe3b7dd7c2,

title = "Molecular epidemiology of geographically dispersed Vibrio Cholerae, Kenya, January 2009-may 2010",

abstract = "Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.",

author = "Mohamed, {Ahmed Abade} and Joseph Oundo and Kariuki, {Samuel M.} and Boga, {Hamadi I.} and Sharif, {Shanaz K.} and Willis Akhwale and Jared Omolo and Amwayi, {Anyangu S.} and David Mutonga and David Kareko and Mercy Njeru and Shan Li and Breiman, {Robert F.} and {Colin Stine}, O.",

year = "2012",

month = jun,

doi = "10.3201/eid1806.111774",

language = "English (US)",

volume = "18",

pages = "925--931",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "6",

}

TY - JOUR

T1 - Molecular epidemiology of geographically dispersed Vibrio Cholerae, Kenya, January 2009-may 2010

AU - Mohamed, Ahmed Abade

AU - Oundo, Joseph

AU - Kariuki, Samuel M.

AU - Boga, Hamadi I.

AU - Sharif, Shanaz K.

AU - Akhwale, Willis

AU - Omolo, Jared

AU - Amwayi, Anyangu S.

AU - Mutonga, David

AU - Kareko, David

AU - Njeru, Mercy

AU - Li, Shan

AU - Breiman, Robert F.

AU - Colin Stine, O.

PY - 2012/6

Y1 - 2012/6

N2 - Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.

AB - Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.

UR - http://www.scopus.com/inward/record.url?scp=84861208259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861208259&partnerID=8YFLogxK

U2 - 10.3201/eid1806.111774

DO - 10.3201/eid1806.111774

M3 - Article

C2 - 22607971

AN - SCOPUS:84861208259

SN - 1080-6040

VL - 18

SP - 925

EP - 931

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 6

ER -

Molecular epidemiology of geographically dispersed Vibrio Cholerae, Kenya, January 2009-may 2010

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this