Molecular epidemiology of Brucella genotypes in patients at a major hospital in central Peru

Karsten Nöckler, Ryan Maves, David Cepeda, Angelika Draeger, Anne Mayer-Scholl, Jesus Chacaltana, María Castañeda, Benjamin Espinosa, Rosa Castillo, Eric Hall, Sascha Al Dahouk, Robert H. Gilman, Franco Cabeza, Henk L. Smits

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The multiple-locus variable-number repeat analysis of 90 human Brucella melitensis isolates from a large urban area in central Peru revealed variations at 4 (Bruce07, Bruce09, Bruce18, and Bruce42) out of 16 loci investigated, of which 1 (Bruce42) also is used for species identification. Ten genotypes were identified, separated by the number of Bruce42 repeats into two groups that may have distinct phenotypic characteristics. Whereas genotypes with five or six Bruce42 repeats were cultured mainly from adult patients, genotypes with three Bruce42 repeats were isolated from children and young adolescents as well as from adults. In addition, the isolates with three Bruce42 repeats were obtained more often from patients with splenomegaly (P = 0.02) or hepatomegaly (P = 0.006). An annual variation in the diversity of genotypes was observed, possibly reflecting changes in sources of fresh dairy products, supply routes to city shops and markets, and the movement of infected dairy goat herds.

Original languageEnglish (US)
Pages (from-to)3147-3155
Number of pages9
JournalJournal of clinical microbiology
Issue number10
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Microbiology (medical)


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