Molecular Determinants of Dysplasia in Colorectal Lesions

Jin Jen, Steve M. Powell, Nickolas Papadopoulos, Kelly J. Smith, Bert Vogelstein, Kenneth W. Kinzler

Research output: Contribution to journalArticlepeer-review

449 Scopus citations


One hallmark of malignant potential is dysplasia, the disruption of normal morphology. While it is generally recognized that cancer is the result of a series of genetic changes, the relationship of these alterations and their timing to the advent of dysplasia remains obscure. To address this issue, 54 small benign colorectal lesions of various malignant potential were analyzed for APC and K-RAS mutations, two alterations which have been Implicated in the early stages of colorectal tumorigenesis. APC mutations were closely associated with dysplasia. In contrast, K-RAS mutations were found to be remarkably common in small nondysplastic lesions which apparently have a limited potential to progress to larger tumors. These results provide evidence that the nature and order of genetic changes can have a specific impact on both tumor morphology dysplasia) and the likelihood of tumor progression.

Original languageEnglish (US)
Pages (from-to)5523-5526
Number of pages4
JournalCancer Research
Issue number21
StatePublished - Nov 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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