Abstract
Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.
Original language | English (US) |
---|---|
Pages (from-to) | 1027-1041 |
Number of pages | 15 |
Journal | Cellular and Molecular Life Sciences |
Volume | 75 |
Issue number | 6 |
DOIs | |
State | Published - Mar 1 2018 |
Keywords
- Cerebral cortex development
- Embryonic neural stem cell
- Epithelial polarity
- Neurogenesis
- Pseudostratified epithelium
- Radial glia
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology