Molecular cloning of the N-terminus of GTBP

Nicholas C. Nicolaides, Fabio Palombo, Kenneth W. Kinzler, Bert Vogelstein, Josef Jiricny

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

Original languageEnglish (US)
Pages (from-to)395-397
Number of pages3
Issue number3
StatePublished - Feb 1 1996

ASJC Scopus subject areas

  • Genetics


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