Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

Christine H. Chung; Joel S. Parker; Gamze Karaca; Junyuan Wu; William K. Funkhouser; Dominic Moore; Dale Butterfoss; Dong Xiang; Adam Zanation; Xiaoying Yin; William W. Shockley; Mark C. Weissler; Lynn G. Dressler; Carol G. Shores; Wendell G. Yarbrough; Charles M. Perou

doi:10.1016/S1535-6108(04)00112-6

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

Christine H. Chung, Joel S. Parker, Gamze Karaca, Junyuan Wu, William K. Funkhouser, Dominic Moore, Dale Butterfoss, Dong Xiang, Adam Zanation, Xiaoying Yin, William W. Shockley, Mark C. Weissler, Lynn G. Dressler, Carol G. Shores, Wendell G. Yarbrough, Charles M. Perou

Research output: Contribution to journal › Article › peer-review

466 Scopus citations

Abstract

The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched subtype, a normal epithelium-like subtype, and a subtype with high levels of antioxidant enzymes. Supervised analyses to predict lymph node metastasis status were approximately 80% accurate when tumor subsite and pathological node status were considered simultaneously. This work represents an important step toward the identification of clinically significant biomarkers for HNSCC.

Original language	English (US)
Pages (from-to)	489-500
Number of pages	12
Journal	Cancer Cell
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/S1535-6108(04)00112-6
State	Published - May 2004
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Cell Biology
Oncology

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10.1016/S1535-6108(04)00112-6

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Chung, C. H., Parker, J. S., Karaca, G., Wu, J., Funkhouser, W. K., Moore, D., Butterfoss, D., Xiang, D., Zanation, A., Yin, X., Shockley, W. W., Weissler, M. C., Dressler, L. G., Shores, C. G., Yarbrough, W. G., & Perou, C. M. (2004). Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell, 5(5), 489-500. https://doi.org/10.1016/S1535-6108(04)00112-6

Chung, CH, Parker, JS, Karaca, G, Wu, J, Funkhouser, WK, Moore, D, Butterfoss, D, Xiang, D, Zanation, A, Yin, X, Shockley, WW, Weissler, MC, Dressler, LG, Shores, CG, Yarbrough, WG & Perou, CM 2004, 'Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression', Cancer Cell, vol. 5, no. 5, pp. 489-500. https://doi.org/10.1016/S1535-6108(04)00112-6

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title = "Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression",

abstract = "The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched subtype, a normal epithelium-like subtype, and a subtype with high levels of antioxidant enzymes. Supervised analyses to predict lymph node metastasis status were approximately 80% accurate when tumor subsite and pathological node status were considered simultaneously. This work represents an important step toward the identification of clinically significant biomarkers for HNSCC.",

author = "Chung, {Christine H.} and Parker, {Joel S.} and Gamze Karaca and Junyuan Wu and Funkhouser, {William K.} and Dominic Moore and Dale Butterfoss and Dong Xiang and Adam Zanation and Xiaoying Yin and Shockley, {William W.} and Weissler, {Mark C.} and Dressler, {Lynn G.} and Shores, {Carol G.} and Yarbrough, {Wendell G.} and Perou, {Charles M.}",

year = "2004",

month = may,

doi = "10.1016/S1535-6108(04)00112-6",

language = "English (US)",

volume = "5",

pages = "489--500",

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T1 - Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

AU - Chung, Christine H.

AU - Parker, Joel S.

AU - Karaca, Gamze

AU - Wu, Junyuan

AU - Funkhouser, William K.

AU - Moore, Dominic

AU - Butterfoss, Dale

AU - Xiang, Dong

AU - Zanation, Adam

AU - Yin, Xiaoying

AU - Shockley, William W.

AU - Weissler, Mark C.

AU - Dressler, Lynn G.

AU - Shores, Carol G.

AU - Yarbrough, Wendell G.

AU - Perou, Charles M.

PY - 2004/5

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N2 - The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched subtype, a normal epithelium-like subtype, and a subtype with high levels of antioxidant enzymes. Supervised analyses to predict lymph node metastasis status were approximately 80% accurate when tumor subsite and pathological node status were considered simultaneously. This work represents an important step toward the identification of clinically significant biomarkers for HNSCC.

AB - The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched subtype, a normal epithelium-like subtype, and a subtype with high levels of antioxidant enzymes. Supervised analyses to predict lymph node metastasis status were approximately 80% accurate when tumor subsite and pathological node status were considered simultaneously. This work represents an important step toward the identification of clinically significant biomarkers for HNSCC.

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VL - 5

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JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

Abstract

ASJC Scopus subject areas

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