Molecular Biology and Immunology of Head and Neck Cancer

Theresa Guo, Joseph A. Califano

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.

Original languageEnglish (US)
Pages (from-to)397-407
Number of pages11
JournalSurgical Oncology Clinics of North America
Issue number3
StatePublished - Jul 1 2015
Externally publishedYes


  • Head and neck cancer
  • Immunology
  • Molecular biology
  • Targeted therapy

ASJC Scopus subject areas

  • Surgery
  • Oncology


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